Man United could be forced to play Young Boys from Old Trafford in their Champions League clash due to Omicron coronavirus.
United will host the Swiss side next Wednesday after having played them in September away from home.
However, Switzerland has changed its quarantine rules to accommodate travellers from Britain and other countries that may have been affected by the new variant.
UEFA guidelines state that Young Boys must be exempted from the 10-day isolation upon returning home. The match must then be moved to a neutral nation.
According to The TelegraphUEFA has been scrambling to figure out the current situation with the Swiss government.
The Red Devils would lose millions of ticket revenues if they moved the match to another location.
A venue change will leave theatre-goers, from home or abroad, disappointed and broke.
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If a neutral country is necessary and cannot be arranged then the game will be delayed until 2022.
After their win over Villarreal by 2-0, United will be in the match with nothing at stake.
They won Group F with one game left thanks to their head to head record against the Spanish side.
United was shocked to lose the reverse fixture against Young Boys earlier in the season.
After Cristiano Ronaldo had opened scoring, Aaron Wan Bissaka was sent off at halftime. However, the game was turned upside down with a last gasp winner.
Although the home team is out of the running, Villarreal can still win to reach the Europa League knockout stage if they beat Atalanta.
The new Swiss rules could have an impact on Gareth Southgate, England manager.
He will be traveling there for the Nations League draw next month.