Scientists are able to reverse the effects of aging in human cells within 30 years


Some scientists predict that by 2100, life expectancy could surpass 130.

However, not everyone wants the world to continue getting older. Scientists have good news for those who want to reverse the clock.

Experts at the Babraham Institute, in Cambridge, have developed a method of reversing ageing in human skin cells – in some cases by up to 30 years.

A paper published in the scientific journal eLife with the catchy title “Multi-omic rejuvenation of human cells by maturation phase transient reprogramming,”The researchers claim that they have restored the function of the aged cells to make them behave like cells decades older.

If the technique could be applied to other types of cells it could be a game-changer for medicine
The technique could be extended to other types of cells, which could make it a game changer in medicine.

Researchers wrote: “The magnitude of rejuvenation instigated by MTPR appears substantially greater than that achieved in previous transient reprogramming protocols.

“In addition, MPTR fibroblasts produced youthful levels of collagen proteins, and showed partial functional rejuvenation of their migration speed.”

It would be revolutionary to just perk up old skin cells. But if this technique could be expanded to other types of cells, it could revolutionize the way we approach medicine.

On average people in the UK live to about 81, but scientists predict we could soon all be celebrating 130th birthdays
Scientists are optimistic about their findings

Professor Wolf Reik is the group leader for the Epigenetics research programme. He said that the work had been transformative. “very exciting implications.

He said: “We may eventually be able identify genes that can rejuvenate without reprogramming and target them to decrease the effects of ageing.

“This approach holds promise for valuable discoveries that could open up an amazing therapeutic horizon.”

Dr Diljeet Gill, a postdoc working with Professor Reik added: “Our understanding of ageing on a molecular level has progressed over the last decade, giving rise to techniques that allow researchers to measure age-related biological changes in human cells.

“We were able to apply this to our experiment to determine the extent of reprogramming our new method achieved.

“Our results represent a big step forward in our understanding of cell reprogramming,” he went on. “We have proved that cells can be rejuvenated without losing their function and that rejuvenation looks to restore some function to old cells.

“The fact that we also saw a reverse of ageing indicators in genes associated with diseases is particularly promising for the future of this work.”